Runtime Verification deals with the question of whether a run of a system adheres to its specification. This paper studies runtime verification in the presence of partial knowledge about the observed run, particularly where input values may not be precise or may not be observed at all. We also allow declaring assumptions on the execution which permits to obtain more precise verdicts also under imprecise inputs. We encode the specification into a symbolic formula that the monitor solves iteratively, when more observations are given. We base our framework on stream runtime verification, which allows to express temporal correctness properties not only in the Boolean but also in richer logical theories. While in general our approach requires to consider larger and larger sets of formulas, we identify domains (including Booleans and Linear Algebra) for which pruning strategies exist, which allow to monitor with constant memory (i.e. independent of the length of the observation) while preserving the same inference power as the monitor that remembers all observations. We empirically exhibit the power of our technique using a prototype implementation under two important case studies: software for testing car emissions and heart-rate monitoring.