Motivated by applications to security and high efficiency, we propose an automated methodology for validating on low-level intermediate representations the results of a source-level static analysis. Our methodology relies on two main ingredients: a relative-safety checker, an instance of a relational verifier which proves that a program is “safer” than another, and a transformation of programs into defensive form which verifies the analysis results at run-time. We prove the soundness of the methodology, and provide a formally verified instantiation based on the Verasco verified C static analyzer and the CompCert verified C compiler. We experiment with the effectiveness of our approach with client optimizations at RTL level, and static analyses for cache-based timing side-channels and memory usage at pre-assembly levels.